Pathway, access, and implementation of Risk-informed cancer prevention across Europe (PARI)

This pilot will develop and test care pathways that adapt cancer prevention strategies to individual risk profiles. More specifically, it will assess the feasibility of delivering large-scale risk-informed cancer prevention in the general population through an international prospective cohort study. The pilot consists of two pillars:

Pillar I: tests the ability to deliver a large-scale, population-based identification of individuals at high risk for different cancers. This will be tested in 3 different settings: primary care; tertiary care; and public health care, across five countries with different levels of readiness for precision prevention.

Pillar II: assesses the ability to provide personalised risk and evidence based care to those identified as high risk in Pillar I.

The project aims to evaluate how feasible, acceptable, effective, fair, and cost-efficient these approaches are, as well as how well systems are prepared to deliver them and how patients experience them. It will also identify the most efficient strategies for different contexts, to support wider future rollout.